SPARC News

SPARC Turns Alzheimer’s Research Into Action in 90 Days When a Cell paper published on April 23, 2025 , proposed a new transcriptional role for PHGDH in the amyloid pathology of Alzheimer’s disease , the UAB Systems Pharmacology AI Research Center (SPARC) didn’t treat it as the finish line—it treated it as a relay handoff . Led by Sixue Zhang, Ph.D. , associate director of SPARC, and Jake Y. Chen, Ph.D. , SPARC’s director, the team mobilized its systems-pharmacology and ge

200,000 Compounds Screened, 3 Novel Drug Scaffolds Identified, and Deep Learning on the Horizon Birmingham, AL – As seasonal and...

Temporal GeneTerrain Maps Dynamic Drug-Induced Pathways in Prostate Cancer Cells Birmingham, AL – A team of biomedical informatics...

A Llama 3-Based Deep Learning Model Outperforms State-of-the-Art Antibody Binding Predictors Birmingham, AL – In a major leap forward...

We’re thrilled to share that our latest research on LRRK2 molecular dynamics (MD) simulations , led by Dr. Bhakat , has just been...

New Multi-Agent AI System Delivers Hypothesis-Driven Drug Discovery at Scale Birmingham, AL – The drug discovery process is long,...

Neuro-Symbolic AI Achieves Record Accuracy in Discovery of Potent Diabetes Drug Candidates Birmingham, AL – Diabetes Mellitus, a chronic...

By leveraging AI in tandem with representative data, the Hub will become a global center of excellence in drug, vaccine, and diagnostics...