October 22, 2025 — Birmingham, AL.  The Systems Pharmacology AI Research Center (SPARC)  at the University of Alabama at Birmingham, led by Professor Jake Y. Chen , has achieved a milestone recognition at the 1st Open Conference of AI Agents for Science 2025  hosted online today by Stanford University. Out of more than 350  paper submissions, only 48  were accepted  after rigorous peer review by 3 AI reviewers and a human expert each, and among them, UAB SPARC’s work was selected as one of...

The “Citrate Queen” visits UAB SPARC on Oct 21st, 2025 CRRT Anticoagulation Challenges and the Risks of Systemic Heparin Continuous renal replacement therapy (CRRT) is a dialysis modality used in critically ill patients with acute kidney injury, especially when hemodynamic instability makes traditional intermittent dialysis unsafe . A major challenge in CRRT is preventing the extracorporeal circuit from clotting without causing patient bleeding. Critically ill patients often have pro...

Jake Y. Chen, PhD Systems Pharmacology Research Center (SPARC) School of Medicine of the University of Alabama at Birmingham...